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KMID : 0363620090300030079
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Journal of Korean Oriental Medicine
2009 Volume.30 No. 3 p.79 ~ p.85
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Four-week Repeated Dose Toxicity Test for Myelophil in SD Rats
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Jung Jong-Mi
Cho Jung-Hyo
Seo Dong-Seok
Seong Nak-Won
Shin Jang-Woo
Son Jin-Young
Son Chang-Gue
Cho Chong-Kwan
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Abstract
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Aim : To evaluate the pharmaceutical safety of the herbal formula Myelophil, composed of Astragali Radix and Salviae Radix, via systemic subacute toxicological study using SD rats.
Methods : Forty male and 40 female SD rats were fed with Myelophil (5000, 2500 or 1250 mg/10 mL/kg) or distilled water for four weeks. Adverse effects were examined intensively by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, hematology, urinalysis, and blood biochemical analysis.
Results : No altered clinical symptoms including body weight, diarrhea, anorexia, death, and abnormal necropsy of major organs were observed in male or female rats. No drug-induced abnormalities in histopathological finding, hematological values, urinalysis, and blood biochemical values were found at any doses of Myelophil.
Conclusion : Myelophil should be very safe when used in a clinical application with a wide therapeutic index.
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KEYWORD
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Myelophil, Astragali Radix, Salviae Radix, herbal remedy, safety, toxicological study
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